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Title: Steroid-Decorated Antibiotic Microparticles for Inhaled Anti-Infective Therapy
Authors: Lee, Sie Huey
Teo, Jeanette
Heng, Desmond
Zhao, Yanli
Ng, Wai Kiong
Chan, Hak-Kim
Tan, Reginald B. H.
Keywords: dry powder inhaler; community-acquired pneumonia (CAP); chronic obstructive pulmonary disease (COPD) ;corticosteroids; combinatorial therapy; spray drying; aerosols;pulmonary drug delivery; formulation; antiinfectives
Issue Date: 2014
Source: Lee, S. H., Teo, J., Heng, D., Zhao, Y., Ng, W. K., Chan, H.-K., et al. (2014). Steroid-Decorated Antibiotic Microparticles for Inhaled Anti-Infective Therapy. Journal of Pharmaceutical Sciences, 103(4), 1115-1125.
Series/Report no.: Journal of Pharmaceutical Sciences
Abstract: Despite advances in vaccination and antimicrobial therapy, community-acquired pneumonia (CAP) remains as a leading cause of morbidity and mortality worldwide. As the severity of CAP has been linked to the extent of inflammation in the body, adjunctive therapeutic measures aimed at modulating the immune response have therefore become increasingly attractive in recent years. In particular, for CAP patients with underlying medical conditions such as chronic obstructive pulmonary disease (COPD), a steroid–antibiotic combination will no doubt be a useful and timely therapeutic intervention. Unfortunately, no combined steroid–antibiotic dry powder formulation is available commercially or has been reported in the academic literature. The aim of this work was hence to develop a novel steroid–antibiotic dry powder inhaler formulation [ciprofloxacin hydrochloride (CIP) and beclomethasone dipropionate (BP)] for inhaled anti-infective therapy. The spray-dried powder was of respirable size (d50 of ∼2.3 μm), partially crystalline and had BP preferentially deposited on the particle surface. Favorably, when formulated as a binary mix, both CIP and BP showed much higher drug release and fine particle fractions (of the loaded dose) over their singly delivered counterparts, and had robust activity against the respiratory tract infection-causing bacteria Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus.
ISSN: 0022-3549
DOI: 10.1002/jps.23874
Schools: School of Materials Science & Engineering 
School of Physical and Mathematical Sciences 
Rights: © 2014 Wiley Periodicals, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Pharmaceutical Sciences, Wiley Periodicals, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles
SPMS Journal Articles

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