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dc.contributor.authorYu, Xiaojunen
dc.contributor.authorLuo, Yuemeien
dc.contributor.authorLiu, Xinyuen
dc.contributor.authorChen, Sien
dc.contributor.authorWang, Xianghongen
dc.contributor.authorChen, Shien
dc.contributor.authorLiu, Linboen
dc.identifier.citationYu, X., Luo, Y., Liu, X., Chen, S., Wang, X., Chen, S., et al. (2016). Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography. IEEE Photonics Journal, 8(4), 3900308-.en
dc.description.abstractThe mucosal microanatomy of the large intestine is characterized by the presence of crypts of Lieberkühn, which is associated predominantly with goblet cells. Such cellular-level intestinal microstructures undergo morphological changes during the progression of bowel diseases, such as colon cancer or ulcerative colitis. As an indicator of gastric cancers, intestinal metaplasia in the large intestine is characterized by the appearance of goblet cells in gastric epithelium, and therefore, visualization of intestinal microstructure changes in cross-sectional view, particularly in vivo, in a high-speed fashion would assist early disease diagnosis and its treatment. In this paper, we investigated the capability of micro-optical coherence tomography (μOCT) for high-speed cellular-level crypt and goblet cell structures imaging ex vivo and in vivo . The adopted μOCT system achieved a resolution of 2.0 μm in both the lateral and axial directions in air. Ex vivo and video-rate in vivo images acquired in 3-D at respective imaging rates of 20 and 60 frames/s are presented and compared with the histology images. Imaging results show that the detailed microstructures, such as the crypt lumen and the goblet cells, could be clearly identified and are also comparable with those in histology images. Such comparisons also indicate that high-resolution μOCT could be a powerful tool to perform “optical biopsy” in colorectal tissue. This is the first work, to the best of our knowledge, on cellular-level structure imaging in intestinal mucosa using spectral-domain OCT.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent9 p.en
dc.relation.ispartofseriesIEEE Photonics Journalen
dc.rights© 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at: [].en
dc.subjectOptical coherence tomographyen
dc.subjectBiophotonics instrumentationen
dc.titleToward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomographyen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen
dc.description.versionPublished versionen
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