Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/81984
Title: Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres
Authors: Harini, Sriram
Venkatesh, Mayandi
Radhakrishnan, Sridhar
Fazil, Mobashar Hussain Urf Turabe
Goh, Eunice Tze Leng
Rui, Sun
Dhand, Chetna
Ong, Seow Theng
Barathi, Veluchamy Amutha
Beuerman, Roger W.
Ramakrishna, Seeram
Verma, Navin Kumar
Lakshminarayanan, Rajamani
Keywords: Electrospinning
Nanofibres
Issue Date: 2016
Source: Harini, S., Venkatesh, M., Radhakrishnan, S., Fazil, M. H. U. T., Goh, E. T. L., Rui, S., et al. (2016). Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres. RSC Advances, 6(47), 41130-41141.
Series/Report no.: RSC Advances
Abstract: Topical skin and nail fungal infections form the most numerous and widespread among superficial mycoses. Drug eluting electrospun nanofibres have been shown to have immense potential for the topical delivery of antimicrobials. In this article, we investigated the efficacy of lecithin-loaded electrospun polycaprolactone (PCL) fibers containing terbinafine hydrochloride (terbinafine) for applications in superficial mycoses. Electron microscopy studies indicated that addition of lecithin and terbinafine decreased the average diameter of PCL nanofibers, increase in mechanical properties and wettability of the fibre mats. PCL mats containing lecithin and terbinafine displayed pronounced blue photoluminescence and did not affect cell adhesion and biocompatibility for primary human dermal fibroblasts. The drug loaded mats maintained the antifungal efficacy against moulds as well as dermatophytic fungus. Using an ex vivo porcine skin infection model, we showed that the drug-eluting mats resulted in >5 log reduction in the viability of T. mentagrophytes.
URI: https://hdl.handle.net/10356/81984
http://hdl.handle.net/10220/41035
DOI: 10.1039/C6RA04755F
Rights: © 2016 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by RSC Advances, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C6RA04755F].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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