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dc.contributor.authorHarini, Sriramen
dc.contributor.authorVenkatesh, Mayandien
dc.contributor.authorRadhakrishnan, Sridharen
dc.contributor.authorFazil, Mobashar Hussain Urf Turabeen
dc.contributor.authorGoh, Eunice Tze Lengen
dc.contributor.authorRui, Sunen
dc.contributor.authorDhand, Chetnaen
dc.contributor.authorOng, Seow Thengen
dc.contributor.authorBarathi, Veluchamy Amuthaen
dc.contributor.authorBeuerman, Roger W.en
dc.contributor.authorRamakrishna, Seeramen
dc.contributor.authorVerma, Navin Kumaren
dc.contributor.authorLakshminarayanan, Rajamanien
dc.identifier.citationHarini, S., Venkatesh, M., Radhakrishnan, S., Fazil, M. H. U. T., Goh, E. T. L., Rui, S., et al. (2016). Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres. RSC Advances, 6(47), 41130-41141.en
dc.description.abstractTopical skin and nail fungal infections form the most numerous and widespread among superficial mycoses. Drug eluting electrospun nanofibres have been shown to have immense potential for the topical delivery of antimicrobials. In this article, we investigated the efficacy of lecithin-loaded electrospun polycaprolactone (PCL) fibers containing terbinafine hydrochloride (terbinafine) for applications in superficial mycoses. Electron microscopy studies indicated that addition of lecithin and terbinafine decreased the average diameter of PCL nanofibers, increase in mechanical properties and wettability of the fibre mats. PCL mats containing lecithin and terbinafine displayed pronounced blue photoluminescence and did not affect cell adhesion and biocompatibility for primary human dermal fibroblasts. The drug loaded mats maintained the antifungal efficacy against moulds as well as dermatophytic fungus. Using an ex vivo porcine skin infection model, we showed that the drug-eluting mats resulted in >5 log reduction in the viability of T. mentagrophytes.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent33 p.en
dc.relation.ispartofseriesRSC Advancesen
dc.rights© 2016 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by RSC Advances, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].en
dc.titleAntifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibresen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.description.versionAccepted versionen
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Appears in Collections:LKCMedicine Journal Articles

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