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dc.contributor.authorLi, Bao-Shengen
dc.contributor.authorWang, Yuhuangen
dc.contributor.authorProctor, Rupert S. J.en
dc.contributor.authorJin, Zhichaoen
dc.contributor.authorChi, Yonggui Robinen
dc.identifier.citationLi, B.-S., Wang, Y., Proctor, R. S. J., Jin, Z., & Chi, Y. R. (2016). Carbene-catalyzed desymmetrization of 1,3-diols: access to optically enriched tertiary alkyl chlorides. Chemical Communications, 52(53), 8313-8316.en
dc.description.abstractThe introduction of a chlorine atom to a carbon center in an enantioselective manner via conventional C–Cl bond formation is difficult. Here we report a new approach to this class of tertiary alkyl chlorides with high optical purities. Instead of forming a new C–Cl bond, our approach involves carbene-catalyzed desymmetrization of 2-chloro-1,3-diols as the key step to set up the chiral carbon center with excellent enantiomeric excess.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent4 p.en
dc.relation.ispartofseriesChemical Communicationsen
dc.rights© 2016 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Chemical Communications, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].en
dc.subjectTertiary alkyl chloridesen
dc.subjectCarbene-catalyzed reactionsen
dc.titleCarbene-catalyzed desymmetrization of 1,3-diols: access to optically enriched tertiary alkyl chloridesen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
dc.description.versionAccepted versionen
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