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Title: Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters
Authors: Chen, Xingkuan
Fong, Jacqueline Zi Mei
Xu, Jianfeng
Mou, Chengli
Lu, Yunpeng
Yang, Song
Song, Bao-An
Chi, Yonggui Robin
Keywords: Carbene-catalyzed reactions
Carboxylic esters
Issue Date: 2016
Source: Chen, X., Fong, J. Z. M., Xu, J., Mou, C., Lu, Y., Yang, S., et al. (2016). Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters. Journal of the American Chemical Society, 138(23), 7212-7215.
Series/Report no.: Journal of the American Chemical Society
Abstract: Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters.
ISSN: 0002-7863
DOI: 10.1021/jacs.6b00406
Schools: School of Physical and Mathematical Sciences 
Rights: © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of the American Chemical Society, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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