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Title: Wound healing profiles of hyperopic-small incision lenticule extraction (SMILE)
Authors: Liu, Yu-Chi
Ang, Heng Pei
Teo, Ericia Pei Wen
Lwin, Nyein Chan
Yam, Gary Hin Fai
Mehta, Jodhbir Singh
Keywords: Cornea
Issue Date: 2016
Source: Liu, Y.-C., Ang, H. P., Teo, E. P. W., Lwin, N. C., Yam, G. H. F., & Mehta, J. S. (2016). Wound healing profiles of hyperopic-small incision lenticule extraction (SMILE). Scientific Reports, 6, 29802-. doi: 10.1038/srep29802
Series/Report no.: Scientific Reports
Abstract: Refractive surgical treatment of hyperopia still remains a challenge for refractive surgeons. A new nomogram of small incision lenticule extraction (SMILE) procedure has recently been developed for the treatment of hyperopia. In the present study, we aimed to evaluate the wound healing and inflammatory responses of this new nomogram (hyperopic-SMILE), and compared them to those of hyperopic-laser-assisted in situ keratomileusis (LASIK), using a rabbit model. A total of 26 rabbits were used, and slit lamp biomicroscopy, autorefractor/keratometer, intraocular pressure measurement, anterior segment optical coherence tomography, corneal topography, and in vivo confocal microscopy examinations were performed during the study period of 4 weeks. The corneas were then harvested and subject to immunofluorescence of markers for inflammation (CD11b), wound healing (fibronectin) and keratocyte response (HSP47). The lenticule ultrastructual changes were also analyzed by transmission electron microscopy. Out results showed that hyperopic-SMILE effectively steepened the cornea. Compared to hyperopic-LASIK, hyperopic-SMILE had less postoperative wound healing response and stromal interface reaction, especially in higher refractive correction. However, compared to myopic-SMILE, hyperopic-SMILE resulted in more central deranged collagen fibrils. These results provide more perspective into this new treatment option for hyperopia, and evidence for future laser nomogram modification.
DOI: 10.1038/srep29802
Rights: © 2016 The Authors (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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