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Title: Strategies for enhancing the sensitivity of plasmonic nanosensors
Authors: Guo, Longhua
Jackman, Joshua A.
Yang, Huang-Hao
Chen, Peng
Cho, Nam-Joon
Kim, Dong-Hwan
Keywords: Sensitivity
Metallic nanoparticles
Plasmonic nanosensors
Localized surface plasmon resonance (LSPR)
Issue Date: 2015
Source: Guo, L., Jackman, J. A., Yang, H. H., Chen, P., Cho, N.-J., & Kim, D.-H. (2015). Strategies for enhancing the sensitivity of plasmonic nanosensors. Nano Today, 10(2), 213-239.
Series/Report no.: Nano Today
Abstract: Based on the localized surface plasmon resonance (LSPR) of metallic nanoparticles, plasmonic nanosensors have emerged as a powerful tool for biosensing applications. Many detection schemes have been developed and the field is rapidly growing to incorporate new methodologies and applications. Amidst all the ongoing research efforts, one common factor remains a key driving force: continued improvement of high-sensitivity detection. Although there are many excellent reviews available that describe the general progress of LSPR-based plasmonic biosensors, there has been limited attention to strategies for improving the sensitivity of plasmonic nanosensors. Recognizing the importance of this subject, this review highlights recent progress on different strategies used for improving the sensitivity of plasmonic nanosensors. These strategies are classified into the following three categories based on their different sensing mechanisms: (1) sensing based on target-induced local refractive index changes, (2) colorimetric sensing based on LSPR coupling, and (3) amplification of detection sensitivity based on nanoparticle growth. The basic principles and cutting-edge examples are provided for each kind of strategy, collectively forming a unifying framework to view the latest attempts to improve the sensitivity of nanoplasmonic sensors. Future trends for the fabrication of improved plasmonic nanosensors are also discussed.
ISSN: 1748-0132
DOI: 10.1016/j.nantod.2015.02.007
Schools: School of Chemical and Biomedical Engineering 
School of Materials Science & Engineering 
Rights: © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles
SCBE Journal Articles

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