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Title: Not just an adhesion molecule : LFA-1 contact tunes the T lymphocyte program
Authors: Verma, Navin Kumar
Kelleher, Dermot
Keywords: DRNTU::Science::Medicine
T Lymphocytes
Issue Date: 2017
Source: Verma, N. K., & Kelleher, D. (2017). Not Just an Adhesion Molecule: LFA-1 Contact Tunes the T Lymphocyte Program. The Journal of Immunology, 199(4), 1213-1221. doi:10.4049/jimmunol.1700495
Series/Report no.: The Journal of Immunology
Abstract: The αLβ2 integrin LFA-1 is known to play a key role in T lymphocyte migration, which is necessary to mount a local immune response, and is also the main driver of autoimmune diseases. This migration-triggering signaling process in T cells is tightly regulated to permit an immune response that is appropriate to the local trigger, as well as to prevent deleterious tissue-damaging bystander effects. Emerging evidence shows that, in addition to prompting a diverse range of downstream signaling cascades, LFA-1 stimulation in T lymphocytes modulates gene-transcription programs, including genetic signatures of TGF-β and Notch pathways, with multifactorial biological outcomes. This review highlights recent findings and discusses molecular mechanisms by which LFA-1 signaling influence T lymphocyte differentiation into the effector subsets Th1, Th17, and induced regulatory T cells. We argue that LFA-1 contact with a cognate ligand, such as ICAM-1, independent of the immune synapse activates a late divergence in T cells’ effector phenotypes, hence fine-tuning their functioning.
ISSN: 0022-1767
DOI: 10.4049/jimmunol.1700495
Rights: © 2017 The American Association of Immunologists, Inc. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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