Please use this identifier to cite or link to this item:
Title: Isolated anterior mediastinal tuberculosis in an immunocompetent patient
Authors: Maguire, S.
Chotirmall, Sanjay Haresh
Parihar, V.
Cormican, L.
Ryan, C.
O’Keane, C
Redmond, K.
Smyth, C.
Keywords: Tuberculosis
Issue Date: 2016
Source: Maguire, S., Chotirmall, S. H., Parihar, V., Cormican, L., Ryan, C., O’Keane, C., et al. (2016). Isolated anterior mediastinal tuberculosis in an immunocompetent patient. BMC Pulmonary Medicine, 16, 24-.
Series/Report no.: BMC Pulmonary Medicine
Abstract: Background: The differential diagnosis of a mediastinal mass is a common challenge in clinical practice, with a wide range of differential diagnosis to be considered. One of the rarer causes is tuberculosis. Atypical presentations of tuberculosis are well documented in immunocompromised patients, but should also be considered in the immunocompetent. Case presentation: This case outlines a previously healthy 22 year-old immunocompetent male presenting with worsening chest pain, positional dyspnea, dry cough and dysphagia. Chest x-ray showed evidence of an isolated anterior mediastinal mass, which was confirmed on computed tomography. A mediastinoscopy was diagnostic as histology revealed necrotizing granulomatous inflammation and the presence of acid-fast bacilli, indicating mediastinal tuberculosis. Conclusion: Typically the underlying presentation of mediastinal tuberculosis is mediastinal lymphadenitis. This case was unusual in that we detected an isolated large anterior mediastinal mass accompanied by a relatively small burden of mediastinal lymphadenitis. Cases similar to this have been documented in immunosuppressed patients however in our case no evidence of immunosuppression was found. This case report emphasizes the importance that a detailed and logical pathway of investigation is pursued when encountering a mediastinal mass.
ISSN: 1471-2466
DOI: 10.1186/s12890-016-0175-7
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2016 Maguire et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
Isolated anterior mediastinal tuberculosis in an immunocompetent patient.pdf1.35 MBAdobe PDFThumbnail

Citations 50

Updated on Sep 25, 2023

Web of ScienceTM
Citations 50

Updated on Sep 24, 2023

Page view(s) 20

Updated on Sep 23, 2023

Download(s) 50

Updated on Sep 23, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.