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dc.contributor.authorHuang, Jiaguoen
dc.contributor.authorLi, Jingchaoen
dc.contributor.authorLyu, Yanen
dc.contributor.authorMiao, Qingqingen
dc.contributor.authorPu, Kanyien
dc.identifier.citationHuang, J., Li, J., Lyu, Y., Miao, Q., & Pu, K. Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury. Nature Materials. doi:10.1038/s41563-019-0378-4en
dc.description.abstractDrug-induced acute kidney injury (AKI) with a high morbidity and mortality is poorly diagnosed in hospitals and deficiently evaluated in drug discovery. Here, we report the development of molecular renal probes (MRPs) with high renal clearance efficiency for in vivo optical imaging of drug-induced AKI. MRPs specifically activate their near-infrared fluorescence or chemiluminescence signals towards the prodromal biomarkers of AKI including the superoxide anion, N-acetyl-β-D-glucosaminidase and caspase-3, enabling an example of longitudinal imaging of multiple molecular events in the kidneys of living mice. Importantly, they in situ report the sequential occurrence of oxidative stress, lysosomal damage and cellular apoptosis, which precedes clinical manifestation of AKI (decreased glomerular filtration). Such an active imaging mechanism allows MRPs to non-invasively detect the onset of cisplatin-induced AKI at least 36 h earlier than the existing imaging methods. MRPs can also act as exogenous tracers for optical urinalysis that outperforms typical clinical/preclinical assays, demonstrating their clinical promise for early diagnosis of AKI.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent39 p.en
dc.relation.ispartofseriesNature Materialsen
dc.rights© 2019 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This paper was published in Nature Materials and is made available with permission of Macmillan Publishers Limited, part of Springer Nature.en
dc.subjectDRNTU::Engineering::Chemical engineeringen
dc.subjectFluorescent Probesen
dc.titleMolecular optical imaging probes for early diagnosis of drug-induced acute kidney injuryen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.description.versionAccepted versionen
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