Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/82615
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dc.contributor.authorLyu, Yanen
dc.contributor.authorCui, Dongen
dc.contributor.authorHuang, Jiaguoen
dc.contributor.authorFan, Wenxuanen
dc.contributor.authorMiao, Yansongen
dc.contributor.authorPu, Kanyien
dc.date.accessioned2019-07-18T02:49:32Zen
dc.date.accessioned2019-12-06T14:59:02Z-
dc.date.available2019-07-18T02:49:32Zen
dc.date.available2019-12-06T14:59:02Z-
dc.date.copyright2019en
dc.date.issued2019en
dc.identifier.citationLyu, Y., Cui, D., Huang, J., Fan, W., Miao, Y., & Pu, K. (2019). Near-infrared afterglow semiconducting nano-polycomplexes for the multiplex differentiation of cancer exosomes. Angewandte Chemie International Edition, 58(15), 4983-4987. doi:10.1002/anie.201900092en
dc.identifier.issn1433-7851en
dc.identifier.urihttps://hdl.handle.net/10356/82615-
dc.description.abstractThe detection of exosomes is promising for the early diagnosis of cancer. However, the development of suitable optical sensors remains challenging. We have developed the first luminescent nanosensor for the multiplex differentiation of cancer exosomes that bypasses real‐time light excitation. The sensor is composed of a near‐infrared semiconducting polyelectrolyte (ASPN) that forms a complex with a quencher‐tagged aptamer. The afterglow signal of the nanocomplex (ASPNC), being initially quenched, is turned on in the presence of aptamer‐targeted exosomes. Because detection of the afterglow takes place after the excitation, background signals are minimized, leading to an improved limit of detection that is nearly two orders of magnitude lower than that of fluorescence detection in cell culture media. Also, ASPNC can be easily tailored to detect different exosomal proteins by changing the aptamer sequence. This enables an orthogonal analysis of multiple exosome samples, potentially permitting an accurate identification of the cellular origin of exosomes for cancer diagnosis.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent5 p.en
dc.language.isoenen
dc.relation.ispartofseriesAngewandte Chemie International Editionen
dc.rightsThis is the peer reviewed version of the following article: Lyu, Y., Cui, D., Huang, J., Fan, W., Miao, Y., & Pu, K. (2019). Near-infrared afterglow semiconducting nano-polycomplexes for the multiplex differentiation of cancer exosomes. Angewandte Chemie International Edition, 58(15), 4983-4987. doi:10.1002/anie.201900092, which has been published in final form at https://dx.doi.org/10.1002/anie.201900092. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectExosomesen
dc.subjectBiosensorsen
dc.subjectEngineering::Chemical engineeringen
dc.titleNear-infrared afterglow semiconducting nano-polycomplexes for multiplex differentiation of cancer exosomesen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1002/anie.201900092en
dc.description.versionAccepted versionen
dc.identifier.rims213962en
item.grantfulltextopen-
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