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Title: Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents
Authors: Sharma, Vijay Kumar
Alipour, A.
Soran-Erdem, Z.
Aykut, Z. G.
Demir, Hilmi Volkan
Keywords: Nanotechnology
Issue Date: 2015
Source: Sharma, V. K., Alipour, A., Soran-Erdem, Z., Aykut, Z. G., & Demir, H. V. (2015). Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents. Nanoscale, 7(23), 10519-10526.
Series/Report no.: Nanoscale
Abstract: We report the first study of highly monodisperse and crystalline iron oxide nanocubes with sub-nm controlled size distribution (9.7 ± 0.5 nm in size) that achieve simultaneous contrast enhancement in both T1- and T2-weighted magnetic resonance imaging (MRI). Here, we confirmed the magnetite structure of iron oxide nanocubes by X-ray diffraction (XRD), selected area electron diffraction (SAED) pattern, optical absorption and Fourier transformed infrared (FT-IR) spectra. These magnetite nanocubes exhibit superparamagnetic and paramagnetic behavior simultaneously by virtue of their finely controlled shape and size. The magnetic measurements reveal that the magnetic moment values are favorably much lower because of the small size and cubic shape of the nanoparticles, which results in an enhanced spin canting effect. As a proof-of-concept demonstration, we showed their potential as dual contrast agents for both T1- and T2-weighted MRI via phantom studies, in vivo imaging and relaxivity measurements. Therefore, these low-magnetization magnetite nanocubes, while being non-toxic and bio-compatible, hold great promise as excellent dual-mode T1 and T2 contrast agents for MRI.
ISSN: 2040-3364
DOI: 10.1039/C5NR00752F
Schools: School of Electrical and Electronic Engineering 
School of Physical and Mathematical Sciences 
Rights: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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