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Title: Endoplasmic reticulum–plasma membrane contact sites
Authors: Saheki, Yasunori
De Camilli, Pietro
Keywords: Oxysterol-binding Protein (OSBP)–related Protein
Extended Synaptotagmins
Issue Date: 2017
Source: Saheki, Y., & De Camilli, P. (2017). Endoplasmic Reticulum–Plasma Membrane Contact Sites. Annual Review of Biochemistry, 86(1), 659-684. doi:10.1146/annurev-biochem-061516-044932
Series/Report no.: Annual Review of Biochemistry
Abstract: The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM). A number of protein tethers that mediate these contacts have been identified, and study of these protein tethers has revealed a multiplicity of roles in cell physiology, including regulation of intracellular Ca2+ dynamics and signaling as well as control of lipid traffic and homeostasis. In this review, we discuss the cross talk between the ER and the PM mediated by direct contacts. We review factors that tether the two membranes, their properties, and their dynamics in response to the functional state of the cell. We focus in particular on the role of ER–PM contacts in nonvesicular lipid transport between the two bilayers mediated by lipid transfer proteins.
ISSN: 0066-4154
DOI: 10.1146/annurev-biochem-061516-044932
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2017 Annual Reviews. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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