Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/82754
Title: | Passive and active ventricular elastances of the left ventricle | Authors: | Zhong, Liang Ghista, Dhanjoo N Ng, Eddie Yin Kwee Lim, Soo Teik |
Keywords: | elasticity Cardiovascular |
Issue Date: | 2005 | Source: | Zhong, L., Ghista, D. N., Ng, E. Y. K., & Lim, S. T. Passive and active ventricular elastances of the left ventricle. BioMedical Engineering OnLine, 4(1), 10-. | Series/Report no.: | BioMedical Engineering OnLine | Abstract: | Background: Description of the heart as a pump has been dominated by models based on elastance and compliance. Here, we are presenting a somewhat new concept of time-varying passive and active elastance. The mathematical basis of time-varying elastance of the ventricle is presented. We have defined elastance in terms of the relationship between ventricular pressure and volume, as: dP = EdV + VdE, where E includes passive (Ep) and active (Ea) elastance. By incorporating this concept in left ventricular (LV) models to simulate filling and systolic phases, we have obtained the time-varying expression for Ea and the LV-volume dependent expression for Ep.Methods and Results: Using the patient's catheterization-ventriculogram data, the values of passive and active elastance are computed. Ea is expressed as: https://static-content.springer.com/image/art%3A10.1186%2F1475-925X-4-10/MediaObjects/12938_2004_Article_82_IEq1_HTML.gif ; Epis represented as: https://static-content.springer.com/image/art%3A10.1186%2F1475-925X-4-10/MediaObjects/12938_2004_Article_82_IEq2_HTML.gif . Ea is deemed to represent a measure of LV contractility. Hence, Peak dP/dt and ejection fraction (EF) are computed from the monitored data and used as the traditional measures of LV contractility. When our computed peak active elastance (Ea,max) is compared against these traditional indices by linear regression, a high degree of correlation is obtained. As regards Ep, it constitutes a volume-dependent stiffness property of the LV, and is deemed to represent resistance-to-filling. Conclusions: Passive and active ventricular elastance formulae can be evaluated from a single-beat P-V data by means of a simple-to-apply LV model. The active elastance (Ea) can be used to characterize the ventricle's contractile state, while passive elastance (Ep) can represent a measure of resistance-to-filling. | URI: | https://hdl.handle.net/10356/82754 http://hdl.handle.net/10220/40346 |
ISSN: | 1475-925X | DOI: | 10.1186/1475-925X-4-10 | Schools: | School of Chemical and Biomedical Engineering School of Mechanical and Aerospace Engineering |
Rights: | © 2005 Zhong et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | MAE Journal Articles SCBE Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Passive and active ventricular elastances of the left ventricle.pdf | 1.2 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
10
37
Updated on Mar 18, 2024
Web of ScienceTM
Citations
10
30
Updated on Oct 30, 2023
Page view(s)
400
Updated on Mar 18, 2024
Download(s) 50
164
Updated on Mar 18, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.