Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/82754
Title: Passive and active ventricular elastances of the left ventricle
Authors: Zhong, Liang
Ghista, Dhanjoo N
Ng, Eddie Yin Kwee
Lim, Soo Teik
Keywords: elasticity
Cardiovascular
Issue Date: 2005
Source: Zhong, L., Ghista, D. N., Ng, E. Y. K., & Lim, S. T. Passive and active ventricular elastances of the left ventricle. BioMedical Engineering OnLine, 4(1), 10-.
Series/Report no.: BioMedical Engineering OnLine
Abstract: Background: Description of the heart as a pump has been dominated by models based on elastance and compliance. Here, we are presenting a somewhat new concept of time-varying passive and active elastance. The mathematical basis of time-varying elastance of the ventricle is presented. We have defined elastance in terms of the relationship between ventricular pressure and volume, as: dP = EdV + VdE, where E includes passive (Ep) and active (Ea) elastance. By incorporating this concept in left ventricular (LV) models to simulate filling and systolic phases, we have obtained the time-varying expression for Ea and the LV-volume dependent expression for Ep.Methods and Results: Using the patient's catheterization-ventriculogram data, the values of passive and active elastance are computed. Ea is expressed as: https://static-content.springer.com/image/art%3A10.1186%2F1475-925X-4-10/MediaObjects/12938_2004_Article_82_IEq1_HTML.gif ; Epis represented as: https://static-content.springer.com/image/art%3A10.1186%2F1475-925X-4-10/MediaObjects/12938_2004_Article_82_IEq2_HTML.gif . Ea is deemed to represent a measure of LV contractility. Hence, Peak dP/dt and ejection fraction (EF) are computed from the monitored data and used as the traditional measures of LV contractility. When our computed peak active elastance (Ea,max) is compared against these traditional indices by linear regression, a high degree of correlation is obtained. As regards Ep, it constitutes a volume-dependent stiffness property of the LV, and is deemed to represent resistance-to-filling. Conclusions: Passive and active ventricular elastance formulae can be evaluated from a single-beat P-V data by means of a simple-to-apply LV model. The active elastance (Ea) can be used to characterize the ventricle's contractile state, while passive elastance (Ep) can represent a measure of resistance-to-filling.
URI: https://hdl.handle.net/10356/82754
http://hdl.handle.net/10220/40346
ISSN: 1475-925X
DOI: 10.1186/1475-925X-4-10
Rights: © 2005 Zhong et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles
SCBE Journal Articles

Files in This Item:
File Description SizeFormat 
Passive and active ventricular elastances of the left ventricle.pdf1.2 MBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations

29
checked on Sep 1, 2020

WEB OF SCIENCETM
Citations

28
checked on Sep 26, 2020

Page view(s)

185
checked on Sep 30, 2020

Download(s)

97
checked on Sep 30, 2020

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.