Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/82758
Title: Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model
Authors: Chandrasekharan, Prashant
Yang, Chang-Tong
Nasrallah, Fatima Ali
Tay, Hui Chien
Chuang, Kai-Hsiang
Robins, Edward G.
Keywords: contrast agent
tumor diagnosis
gadolinium chelate
magnetic resonance imaging (MRI)
pharmacokinetics
orthotopic glioma model
Issue Date: 2015
Source: Chandrasekharan, P., Yang, C.-T., Nasrallah, F. A., Tay, H. C., Chuang, K.-H., & Robins, E. G. (2015). Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model. Contrast Media & Molecular Imaging, 10(3), 237-244.
Series/Report no.: Contrast Media & Molecular Imaging
Abstract: Pharmacokinetics of Gd(DO3A-Lys), a macrocyclic gadolinium based MRI contrast agent functionalized with a lysine derivative, was studied in Wistar rats. Kinetic data was fitted using a two compartment model and revealed Gd(DO3A-Lys) to have a distribution half-life, t1/2(alpha), of 1.3 min, an elimination half-life, t1/2(beta), of 24.9 min and a large volume of distribution, VD, of 0.49 L/kg indicative of the agent being able to rapidly distribute into tissues and organs. Contrast enhanced magnetic resonance angiography (CEMRA) in an orthotopic U87MG glioma mouse model demonstrated considerable enhancement of both the tumor and surrounding vasculature after intravenous administration of Gd(DO3A-Lys). Applying dynamic contrast enhanced magnetic resonance imaging (DCEMRI) in the glioma of different sizes further showed distinct uptake characteristics and patterns of enhancement, which suggests the potential for differentiating changes at different stages of tumor growth. Our results indicate that Gd(DO3A-Lys) could be a promising candidate for glioma MR imaging.
URI: https://hdl.handle.net/10356/82758
http://hdl.handle.net/10220/40315
ISSN: 1555-4309
DOI: 10.1002/cmmi.1634
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2015 John Wiley & Sons, Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Contrast Media and Molecular Imaging, John Wiley & Sons, Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/cmmi.1634].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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