Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/82764
Title: A dual function theranostic agent for near-infrared photoacoustic imaging and photothermal therapy
Authors: Upputuri, Paul Kumar
Huang, Shuo
Wang, Mingfeng
Pramanik, Manojit
Keywords: Photothermal therapy
Pulsed diode laser
Photoacoustic imaging
Organic nanoparticles
Contrast agent
Deep-tissue imaging
Issue Date: 2016
Source: Upputuri, P. K., Huang, S., Wang, M., & Pramanik, M. (2015). A dual function theranostic agent for near-infrared photoacoustic imaging and photothermal therapy. Proceedings of SPIE - Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VIII, 9723.
Abstract: Theranostic, defined as combining diagnostic and therapeutic agents, has attracted more attention in biomedical application. It is essential to monitor diseased tissue before treatment. Photothermal therapy (PTT) is a promising treatment of cancer tissue due to minimal invasion, unharmful to normal tissue and high efficiency. Photoacoustic tomography (PAT) is a hybrid nonionizing biomedical imaging modality that combines rich optical contrast and high ultrasonic resolution in a single imaging modality. The near infra-red (NIR) wavelengths, usually used in PAT, can provide deep penetration at the expense of reduced contrast, as the blood absorption drops in the NIR range. Exogenous contrast agents with strong absorption in the NIR wavelength range can enhance the photoacoustic imaging contrast as well as imaging depth. Most theranostic agents incorporating PAT and PTT are inorganic nanomaterials that suffer from poor biocompatibility and biodegradability. Herein, we present an benzo[1,2-c;4,5-c’] bis[1,2,5] thiadiazole (BBT), based theranostic agent which not only acts as photoacoustic contrast agent but also a photothermal therapy agent. Experiments were performed on animal blood and organic nanoparticles embedded in a chicken breast tissue using PAT imaging system at ~803 nm wavelengths. Almost ten time contrast enhancement was observed from the nanoparticle in suspension. More than 6.5 time PA signal enhancement was observed in tissue at 3 cm depth. HeLa cell lines was used to test photothermal effect showing 90% cells were killed after 10 min laser irradiation. Our results indicate that the BBT - based naoparticles are promising theranostic agents for PAT imaging and cancer treatment by photothermal therapy.
URI: https://hdl.handle.net/10356/82764
http://hdl.handle.net/10220/40365
DOI: 10.1117/12.2211947
Rights: © 2015 Society of Photo-Optical Instrumentation Engineers (SPIE). This paper was published in Proceedings of SPIE - Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VIII and is made available as an electronic reprint (preprint) with permission of Society of Photo-Optical Instrumentation Engineers (SPIE). The paper can be found at the following official DOI: [http://dx.doi.org/10.1117/12.2211947]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Conference Papers

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