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Title: Measures and Indices for Intrinsic Characterization of Cardiac Dysfunction during Filling & Systolic Ejection
Authors: Zhong, Liang
Ghista, Dhanjoo N.
Lim, Soo Teik
Chua, Siang Jin
Ng, Yin Kwee
Keywords: ventricular function
Heart failure
Issue Date: 2005
Source: Zhong, L., Ghista, D. N., Ng, Y. K., Lim, S. T., & Chua, S. J. (2005). Measures and Indices for Intrinsic Characterization of Cardiac Dysfunction during Filling & Systolic Ejection. Journal of Mechanics in Medicine and Biology, 5(2), 307-332.
Series/Report no.: Journal of Mechanics in Medicine and Biology
Abstract: The paper discusses the development and application of bioengineering indices for reliable diagnosis of cardiac functional modalities in filling and contraction phases. During diastolic filling, the left-ventricular (LV) volume developed is a response to left-atrium (LV) suction at early rapid filling and LA contraction at late filling. However, in LV ejection, the LV flow-rate and aortic pressure constitute response to LV myocardial stress and intra-LV pressure generation. The differential equations used in the governing of these relationships have been developed. By matching the solutions of these differential equations with the clinical data of LV volume and pressure, we can determine the heart model "differential equations" parameters, as well as the derived indices. These parameters and indices include: compliance and resistance-to-filling for characterizing diastolic-filling function, together with the index of LV contractility (in terms of maximum LV contractile power and stress-velocity relationship for contractile element). By evaluating them, it is possible to diagnose more reliably and differentially heart diseases due to an increase in filling-resistance and contractility abnormalities.
ISSN: 0219-5194
DOI: 10.1142/S0219519405001369
Schools: School of Chemical and Biomedical Engineering 
School of Mechanical and Aerospace Engineering 
Rights: © 2005 World Scientific Publishing Company. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Mechanics in Medicine and Biology, World Scientific Publishing Company. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
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