Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/82779
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dc.contributor.authorChian, Kerm Sinen
dc.contributor.authorLeong, Meng Fatten
dc.contributor.authorKono, Kojien
dc.date.accessioned2015-06-08T06:36:33Zen
dc.date.accessioned2019-12-06T15:05:23Z-
dc.date.available2015-06-08T06:36:33Zen
dc.date.available2019-12-06T15:05:23Z-
dc.date.copyright2015en
dc.date.issued2015en
dc.identifier.citationChian, K. S., Leong, M. F., & Kono, K. (2015). Regenerative medicine for oesophageal reconstruction after cancer treatment. The lancet oncology, 16(2), e84-e92.en
dc.identifier.issn1470-2045en
dc.identifier.urihttps://hdl.handle.net/10356/82779-
dc.description.abstractRemoval of malignant tissue in patients with oesophageal cancer and replacement with autologous grafts from the stomach and colon can lead to problems. The need to reduce stenosis and anastomotic leakage after oesophagectomy is a high priority. Developments in tissue-engineering methods and cell-sheet technology have improved scaffold materials for oesophageal repair. Despite the many successful animal studies, few tissue-engineering approaches have progressed to clinical trials. In this Review, we discuss the status of oesophagus reconstruction after surgery. In particular, we highlight two clinical trials that used decellularised constructs and epithelial cell sheets to replace excised tissues after endoscopic submucosal dissection or mucosal resection procedures. Results from the trials showed that both decellularised grafts and epithelial-cell sheets prevented stenosis. By contrast, animal studies have shown that the use of tissue-engineered constructs after oesophagectomy remains a challenge.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.format.extent9 p.en
dc.language.isoenen
dc.relation.ispartofseriesThe lancet oncologyen
dc.rights© 2015 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by The Lancet Oncology, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/S1470-2045(14)70410-3].en
dc.subjectDRNTU::Science::Medicine::Tissue engineeringen
dc.titleRegenerative medicine for oesophageal reconstruction after cancer treatmenten
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen
dc.identifier.doi10.1016/S1470-2045(14)70410-3en
dc.description.versionAccepted Versionen
item.fulltextWith Fulltext-
item.grantfulltextopen-
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