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dc.contributor.authorDuan, Boen
dc.contributor.authorZhou, Jiajingen
dc.contributor.authorFang, Zhengen
dc.contributor.authorWang, Chenxuen
dc.contributor.authorWang, Xiujuanen
dc.contributor.authorHemond, Harold F.en
dc.contributor.authorChan-Park, Mary B.en
dc.contributor.authorDuan, Hongweien
dc.identifier.citationDuan, B., Zhou, J., Fang, Z., Wang, C., Wang, X., Hemond, H. F., et al. (2015). Surface enhanced Raman scattering by graphene-nanosheet-gapped plasmonic nanoparticle arrays for multiplexed DNA detection. Nanoscale, 7(29), 12606-12613.en
dc.description.abstractWe have developed a new type of surface enhanced Raman scattering (SERS) substrate with thiolated graphene oxide (tGO) nanosheets sandwiched between two layers of closely packed plasmonic nanoparticles. The trilayered substrate is built up through alternative loading of interfacially assembled plasmonic nanoparticle arrays and tGO nanosheets, followed by coating the nanoparticle surfaces with poly(ethylene glycol) (PEG). Here tGO plays multifunctional roles as a 2D scaffold to immobilized interfacially assembled plasmonic nanoparticles, a nanospacer to create SERS-active nanogaps between two layers of nanoparticle arrays, and a molecule harvester to enrich molecules of interest via π–π interaction. In particular, the molecule harvesting capability of the tGO nanospacer and the stealth properties of PEG coating on the plasmonic nanoparticles collectively lead to preferential positioning of selective targets such as aromatic molecules and single-stranded DNA at the SERS-active nanogap hotspots. We have demonstrated that an SERS assay based on the PEGylated trilayered substrate, in combination with magnetic separation, allows for sensitive, multiplexed “signal-off” detection of DNA sequences of bacterial pathogens.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent8 p.en
dc.rights© 2015 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.en
dc.subjectDensity functional theory (DFT)en
dc.titleSurface enhanced Raman scattering by graphene-nanosheet-gapped plasmonic nanoparticle arrays for multiplexed DNA detectionen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.description.versionPublished versionen
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