Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/82827
Title: Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
Authors: Mathiyazhakan, Malathi
Chan, Weiwei
Ohl, Claus-Dieter
Xu, Chenjie
Keywords: Issue 108
Exogenous stimuli-responsive nanoparticles
controlled release
Bioengineering
microbubble cavitation
light-responsive liposomes
gold nanoparticles
drug delivery
Issue Date: 2016
Source: Mathiyazhakan, M., Chan, W., Ohl, C.-D., & Xu, C. (2016). Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation. Journal of Visualized Experiments, (108), e53619-.
Series/Report no.: Journal of Visualized Experiments
Abstract: Photo-responsive nanoparticles (NPs) have received considerable attention because of their potential in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the development process and are unprocurable by clinics. Here, we describe a facile fabrication of these photo-responsive NPs with commercially available gold NPs and thermo-responsive liposomes Calcein is used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Finally, we show that this photo-triggered release is due to the membrane disruption caused by microbubble cavitation, which can be measured with hydrophone.
URI: https://hdl.handle.net/10356/82827
http://hdl.handle.net/10220/40305
ISSN: 1940-087X
DOI: 10.3791/53619
Rights: © 2016 Journal of Visualized Experiments. This paper was published in Journal of Visualized Experiments and is made available as an electronic reprint (preprint) with permission of Journal of Visualized Experiments. The published version is available at: [http://dx.doi.org/10.3791/53619]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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