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Title: Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators
Authors: Bai, Zhiqiang
Chai, Xiao-ran
Yoon, Myeong Jin
Kim, Hye-Jin
LO, Kinyui Alice
Zhang, Zhi-chun
Xu, Dan
Teh, Diana Chee Siang
Walet, Arcinas Camille Esther
Xu, Shao-hai
Chia, Sook-Yoong
Chen, Peng
Yang, Hongyuan
Ghosh, Sujoy
Sun, Lei
Keywords: Adipose Tissue
Protein RNA Binding
Issue Date: 2017
Source: Bai, Z., Chai, X.-R., Yoon, M. J., Kim, H.-J., LO, K. A., Zhang, Z.-C., et al. (2017). Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators. PLOS Biology, 15(8), e2002176-.
Series/Report no.: PLOS Biology
Abstract: Enhancing brown fat activity and promoting white fat browning are attractive therapeutic strategies for treating obesity and associated metabolic disorders. To provide a comprehensive picture of the gene regulatory network in these processes, we conducted a series of transcriptome studies by RNA sequencing (RNA-seq) and quantified the mRNA and long noncoding RNA (lncRNA) changes during white fat browning (chronic cold exposure, beta-adrenergic agonist treatment, and intense exercise) and brown fat activation or inactivation (acute cold exposure or thermoneutrality, respectively). mRNA–lncRNA coexpression networks revealed dynamically regulated lncRNAs to be largely embedded in nutrient and energy metabolism pathways. We identified a brown adipose tissue–enriched lncRNA, lncBATE10, that was governed by the cAMP-cAMP response element-binding protein (Creb) axis and required for a full brown fat differentiation and white fat browning program. Mechanistically, lncBATE10 can decoy Celf1 from Pgc1α, thereby protecting Pgc1α mRNA from repression by Celf1. Together, these studies provide a comprehensive data framework to interrogate the transcriptomic changes accompanying energy homeostasis transition in adipose tissue.
ISSN: 1544-9173
DOI: 10.1371/journal.pbio.2002176
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2017 Bai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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