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Title: A four-dimensional snapshot hyperspectral video-endoscope for bio-imaging applications
Authors: Lim, Hoong-Ta
Matham, Murukeshan Vadakke
Keywords: Mechanical and Aerospace Engineering
Issue Date: 2016
Source: Lim, H.-T., & Murukeshan, V. M. (2016). A four-dimensional snapshot hyperspectral video-endoscope for bio-imaging applications. Scientific Reports, 6, 24044-.
Series/Report no.: Scientific Reports
Abstract: Hyperspectral imaging has proven significance in bio-imaging applications and it has the ability to capture up to several hundred images of different wavelengths offering relevant spectral signatures. To use hyperspectral imaging for in vivo monitoring and diagnosis of the internal body cavities, a snapshot hyperspectral video-endoscope is required. However, such reported systems provide only about 50 wavelengths. We have developed a four-dimensional snapshot hyperspectral video-endoscope with a spectral range of 400–1000 nm, which can detect 756 wavelengths for imaging, significantly more than such systems. Capturing the three-dimensional datacube sequentially gives the fourth dimension. All these are achieved through a flexible two-dimensional to one-dimensional fiber bundle. The potential of this custom designed and fabricated compact biomedical probe is demonstrated by imaging phantom tissue samples in reflectance and fluorescence imaging modalities. It is envisaged that this novel concept and developed probe will contribute significantly towards diagnostic in vivo biomedical imaging in the near future.
ISSN: 2045-2322
DOI: 10.1038/srep24044
Schools: School of Mechanical and Aerospace Engineering 
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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