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Title: Control of skilled movement by the cerebellar interposed anterior nucleus
Authors: Thanawalla, Ayesha Rustom
Keywords: DRNTU::Science::Biological sciences::Molecular biology
Issue Date: 2018
Source: Thanawalla, A. R. (2018). Control of skilled movement by the cerebellar interposed anterior nucleus. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: As the output channels of the cerebellum, the deep cerebellar nuclei (DCN) represent an important element of cerebellar circuits for control of voluntary movements. In this study, we address the role of neurons in the DCN using the Ucn3::Cre mouse which drives recombination in the interposed anterior nucleus (IntA). Manipulation of IntA neurons resulted in deficits in the kinematic parameters of limb movement during skilled reaching and locomotion. Furthermore, IntA neurons were also found to reduce activity in extensor muscle synergies. Finally, we present anatomical evidence that suggests neurons in the IntA nucleus may influence movement through cerebello-thalamo-cortical and/or rubrospinal pathways. Together, we identified a novel genetic tool for the interrogation of the connectivity and function of the IntA nucleus and defined the functional significance of a subpopulation of neurons in the IntA nucleus.
DOI: 10.32657/10220/47544
Schools: School of Biological Sciences 
Research Centres: NTU-Warwick Neuroscience Program 
Fulltext Permission: open
Fulltext Availability: With Fulltext
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