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Title: Chitinase activation in patients with fungus-associated cystic fibrosis lung disease
Authors: Hector, Andreas
Chotirmall, Sanjay Haresh
Lavelle, Gillian M.
Mirković, Bojana
Horan, Deirdre
Eichler, Laura
Mezger, Markus
Singh, Anurag
Ralhan, Anjai
Berenbrinker, Sina
Mack, Ines
Ensenauer, Regina
Riethmüller, Joachim
Graepler-Mainka, Ute
Murray, Michelle A.
Griese, Matthias
Gerry McElvaney, N.
Hartl, Dominik
Keywords: Cystic fibrosis
Lung disease
Issue Date: 2016
Source: Hector, A., Chotirmall, S. H., Lavelle, G. M., Mirković, B., Horan, D., Eichler, L., et al. (2016). Chitinase activation in patients with fungus-associated cystic fibrosis lung disease. Journal of Allergy and Clinical Immunology, 138(4), 1183-1189.e4.
Series/Report no.: Journal of Allergy and Clinical Immunology
Abstract: BACKGROUND: Chitinases have recently gained attention in the field of pulmonary diseases, particularly in asthma and chronic obstructive pulmonary disease, but their potential role in patients with cystic fibrosis (CF)-associated lung disease remains unclear. OBJECTIVE: The aim of this study was to assess chitinase activity systemically and in the airways of patients with CF and asthma compared with healthy subjects. Additionally, we assessed factors that regulate chitinase activity within the lungs of patients with CF. METHODS: Chitinase activities were quantified in serum and bronchoalveolar lavage fluid from patients with CF, asthmatic patients, and healthy control subjects. Mechanistically, the role of CF airway proteases and genetic chitinase deficiency was assessed. RESULTS: Chitinase activity was systemically increased in patients with CF compared with that in healthy control subjects and asthmatic patients. Further stratification showed that chitinase activity was enhanced in patients with CF colonized with Candida albicans compared with that in noncolonized patients. CF proteases degraded chitinases in the airway microenvironment of patients with CF. Genetic chitinase deficiency was associated with C albicans colonization in patients with CF. CONCLUSION: Patients with CF have enhanced chitinase activation associated with C albicans colonization. Therefore chitinases might represent a novel biomarker and therapeutic target for CF-associated fungal disease.
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2016.01.031
Rights: © 2016 American Academy of Allergy, Asthma & Immunology
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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