Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83023
Title: Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma
Authors: Goh, Ken Junyang
Yii, Anthony Chau Ang
Lapperre, Therese Sophie
Chan, Adrian K. W.
Chew, Fook Tim
Chotirmall, Sanjay Haresh
Koh, Mariko Siyue
Keywords: Airway
Atopy
Issue Date: 2017
Source: Goh, K. J., Yii, A. C. A., Lapperre, T. S., Chan, A. K. W., Chew, F. T., Chotirmall, S. H., et al. (2017). Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma. Journal of Asthma and Allergy, 10, 131-140.
Series/Report no.: Journal of Asthma and Allergy
Abstract: BACKGROUND: Severe asthma is a largely heterogeneous disease with varying phenotypic profiles. The relationship between specific allergen sensitization and asthma severity, particularly in Asia, remains unclear. We aim to study the prevalence of specific allergen sensitization patterns and investigate their association with outcomes in a severe asthma cohort in an Asian setting. METHODS: We conducted a cross-sectional study of patients receiving step 4 or 5 Global Initiative for Asthma treatment. Univariate and multivariate analyses were performed to assess the association between sensitization to a specific identifiable allergen by skin prick test (SPT) and uncontrolled asthma (defined in our study as the use of ≥2 steroid bursts or hospitalization in the past year, a history of near-fatal asthma or evidence of airflow obstruction on spirometry). RESULTS: Two hundred and six severe asthma patients (mean age 45±17 years, 99 [48.1%] male) were evaluated. Of them, 78.2% had a positive SPT to one or more allergens. The most common allergen to which patients were sensitized was house dust mites (Blomia tropicalis, Dermatophagoides pteronyssinus and Dermatophagoides farinae). Also, 11.7% were sensitized to Aspergillus species. On multivariate analysis, Aspergillus sensitization was associated with uncontrolled asthma (odds ratio 6.07, 95% confidence interval 1.80-20.51). In particular, Aspergillus sensitization was independently associated with the use of ≥2 steroid bursts in the past year (odds ratio 3.05, 95% confidence interval 1.04-8.95). No similar associations of uncontrolled asthma with sensitization to any other allergens were found. CONCLUSION: High allergen, specifically Aspergillus sensitization was observed in the Asian population with severe asthma by SPT. Aspergillus sensitization was specifically associated with frequent exacerbations and a greater corticosteroid requirement. An improved understanding of the severe asthma with Aspergillus sensitization phenotype is warranted, which is likely a subgroup of severe asthma with fungal sensitization.
URI: https://hdl.handle.net/10356/83023
http://hdl.handle.net/10220/42387
ISSN: 1178-6965
DOI: 10.2147/JAA.S130459
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2017 Goh et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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