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Title: Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase
Authors: Kundu, Subhashri
Biukovic, Goran
Grüber, Gerhard
Dick, Thomas
Keywords: F-ATP synthase
ε subunit
Issue Date: 2016
Source: Kundu, S., Biukovic, G., Grüber, G., & Dick, T. (2016). Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase. Antimicrobial Agents and Chemotherapy, 60(11), 6977-6979.
Series/Report no.: Antimicrobial Agents and Chemotherapy
Abstract: The tuberculosis drug bedaquiline inhibits mycobacterial F-ATP synthase by binding to its c subunit. Using the purified ε subunit of the synthase and spectroscopy, we previously demonstrated that the drug interacts with this protein near its unique tryptophan residue. Here, we show that replacement of ε's tryptophan with alanine resulted in bedaquiline hypersusceptibility of the bacteria. Overexpression of the wild-type ε subunit caused resistance. These results suggest that the drug also targets the ε subunit.
ISSN: 0066-4804
DOI: 10.1128/AAC.01291-16
Schools: School of Biological Sciences 
Rights: © 2016 Kundu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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