Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83127
Title: Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions
Authors: Kwok, Immanuel Weng Han
Leong, Penny Hweixian
Evrard, Maximilien
Chong, Shu Zhen
Teng, Karen W.W.
Becht, Etienne
Chen, Jinmiao
Sieow, Je Lin
Ching, Goh Chi
Devi, Sapna
Adrover, José Maria
Li, Jackson L.Y.
Liong, Ka Hang
Tan, Leonard
Poon, Zhiyong
Foo, Shihui
Chua, Jia Wang
Su, I-Hsin
Balabanian, Karl
Bachelerie, Françoise
Biswas, Subhra K.
Larbi, Anis
Hwang, William Y.K.
Madan, Vikas
Koeffler, H. Phillip
Wong, Siew Cheng
Newell, Evan W.
Hidalgo, Andrés
Ginhoux, Florent
Ng, Lai Guan
Keywords: Granulopoiesis
Trafficking
Science::Biological sciences
Issue Date: 2018
Source: Evrard, M., Kwok, I. W. H., Chong, S. Z., Teng, K. W. W., Becht, E., Chen, J., . . . Ng, L. G. (2018). Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions. Immunity, 48(2), 364-379, e1-e8. doi:10.1016/j.immuni.2018.02.002
Series/Report no.: Immunity
Abstract: Neutrophils are specialized innate cells that require constant replenishment from proliferative bone marrow (BM) precursors as a result of their short half-life. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the differentiation pathways from GMP to functional mature neutrophils are poorly defined. Using mass cytometry (CyTOF) and cell-cycle-based analysis, we identified three neutrophil subsets within the BM: a committed proliferative neutrophil precursor (preNeu) which differentiates into non-proliferating immature neutrophils and mature neutrophils. Transcriptomic profiling and functional analysis revealed that preNeu require the C/EBPε transcription factor for their generation from the GMP, and their proliferative program is substituted by a gain of migratory and effector function as they mature. preNeus expand under microbial and tumoral stress, and immature neutrophils are recruited to the periphery of tumor-bearing mice. In summary, our study identifies specialized BM granulocytic populations that ensure supply under homeostasis and stress responses.
URI: https://hdl.handle.net/10356/83127
http://hdl.handle.net/10220/50413
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2018.02.002
Rights: © 2018 Elsevier Inc. All rights reserved. This paper was published in Immunity and is made available with permission of Elsevier Inc.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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