Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83135
Title: The role of angiopoietin-like 4 (ANGPTL4) in chemoresistance and autophangy during epithelial-mesenchymal transition (EMT)
Authors: Lim, Maegan Miang Kee
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2019
Source: Lim, M. M. K. (2019). The role of angiopoietin-like 4 (ANGPTL4) in chemoresistance and autophangy during epithelial-mesenchymal transition (EMT). Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Patients with metastatic cancers often displayed multidrug resistance (MDR) and emerging studies have shown that the Angiopoietin-like 4 (ANGPTL4) protein plays critical roles in metastatic dissemination of cancer cells during epithelial-mesenchymal transition (EMT), an early stage event during cancer metastasis. Our studies demonstrated that ANGPTL4 confers MDR phenotype to metastatic cells via ATP-binding cassette (ABC) transporters expression and activities, as well as coordinating cellular bioenergetics and increasing cellular adenylate energy charge via regulation of glucose and lipid metabolism and autophagy to providing for energy demanding processes during EMT. This suggests that strategies to suppress ANGPTL4 expression and function, may provide a dynamic therapeutic intervention in overcoming MDR in metastatic cancers.
URI: https://hdl.handle.net/10356/83135
http://hdl.handle.net/10220/47586
DOI: 10.32657/10220/47586
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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