Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83148
Full metadata record
DC FieldValueLanguage
dc.contributor.authorQian, Xingen
dc.contributor.authorCastellanos, Francisco Xavieren
dc.contributor.authorUddin, Lucina Q.en
dc.contributor.authorLoo, Beatrice Rui Yien
dc.contributor.authorLiu, Siweien
dc.contributor.authorKoh, Hui Lien
dc.contributor.authorFung, Danielen
dc.contributor.authorGuan, Cuntaien
dc.contributor.authorLee, Tih-Shihen
dc.contributor.authorLim, Choon Guanen
dc.contributor.authorZhou, Juanen
dc.contributor.authorPoh, Wendy Xue Weien
dc.date.accessioned2019-07-03T06:18:35Zen
dc.date.accessioned2019-12-06T15:12:45Z-
dc.date.available2019-07-03T06:18:35Zen
dc.date.available2019-12-06T15:12:45Z-
dc.date.issued2018en
dc.identifier.citationQian, X., Castellanos, F. X., Uddin, L. Q., Loo, B. R. Y., Liu, S., Koh, H. L., . . . Zhou, J. (2019). Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder. NeuroImage: Clinical, 21, 101600-. doi:10.1016/j.nicl.2018.11.010en
dc.identifier.urihttps://hdl.handle.net/10356/83148-
dc.description.abstractAccumulating evidence suggests brain network dysfunction in attention-deficit/hyperactivity disorder (ADHD). Whether large-scale brain network connectivity patterns reflect clinical heterogeneity in ADHD remains to be fully understood. This study aimed to characterize the differential within- and between-network functional connectivity (FC) changes in children with ADHD combined (ADHD-C) or inattentive (ADHD-I) subtypes and their associations with ADHD symptoms. We studied the task-free functional magnetic resonance imaging (fMRI) data of 58 boys with ADHD and 28 demographically matched healthy controls. We measured within- and between-network connectivity of both low-level (sensorimotor) and high-level (cognitive) large-scale intrinsic connectivity networks and network modularity. We found that children with ADHD-C but not those with ADHD-I exhibited hyper-connectivity within the anterior default mode network (DMN) compared with controls. Additionally, children with ADHD-C had higher inter-network FC between the left executive control (ECN) and the salience (SN) networks, between subcortical and visual networks, and between the DMN and left auditory networks than controls, while children with ADHD-I did not show differences compared with controls. Similarly, children with ADHD-C but not ADHD-I showed lower network modularity compared with controls. Importantly, these observed abnormal inter-network connectivity and network modularity metrics were associated with Child Behavioral Checklist (CBCL) attention-deficit/hyperactivity problems and internalizing problems in children with ADHD. This study revealed relatively greater loss of brain functional network segregation in childhood ADHD combined subtype compared to the inattentive subtype, suggesting differential large-scale functional brain network topology phenotype underlying childhood ADHD heterogeneity.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.description.sponsorshipMOH (Min. of Health, S’pore)en
dc.format.extent8 p.en
dc.language.isoenen
dc.relation.ispartofseriesNeuroImage: Clinicalen
dc.rights© 2018 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en
dc.subjectFunctional Connectivityen
dc.subjectEngineering::Computer science and engineeringen
dc.subjectAttention-deficit/Hyperactivity Disorderen
dc.titleLarge-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorderen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Computer Science and Engineeringen
dc.identifier.doi10.1016/j.nicl.2018.11.010en
dc.description.versionPublished versionen
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:SCSE Journal Articles
Files in This Item:
File Description SizeFormat 
Large-scale brain functional network topology disruptions underlie.pdf3.3 MBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 10

61
Updated on Jul 17, 2024

Web of ScienceTM
Citations 10

49
Updated on Oct 29, 2023

Page view(s) 50

455
Updated on Jul 22, 2024

Download(s) 50

77
Updated on Jul 22, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.