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Title: Role of lncRNAs in Cellular Aging
Authors: Degirmenci, Ufuk
Lei, Sun
Keywords: Senescence
Issue Date: 2016
Source: Degirmenci, U.,& Lei, S. (2016). Role of lncRNAs in Cellular Aging. Frontiers in Endocrinology, 7.
Series/Report no.: Frontiers in Endocrinology
Abstract: Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence.
ISSN: 1664-2392
DOI: 10.3389/fendo.2016.00151
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2016 Degirmenci and Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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