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Title: Separation of pathogenic bacteria by chain length
Authors: Beech, Jason P.
Ho, Bao Dang
Garriss, Geneviève
Oliveira, Vitor
Henriques-Normark, Birgitta
Tegenfeldt, Jonas O.
Keywords: Deterministic Lateral Displacement
Issue Date: 2018
Source: Beech, J. P., Ho, B. D., Garriss, G., Oliveira, V., Henriques-Normark, B.,& Tegenfeldt, J. O. (2018). Separation of pathogenic bacteria by chain length. Analytica Chimica Acta, 1000223-231.
Series/Report no.: Analytica Chimica Acta
Abstract: Using Deterministic Lateral Displacement devices optimized for sensitivity to particle length, we separatesubpopulations of bacteria depending on known properties that affect their capability to cau se disease(virulence). For the human bacterial pathogen Streptococcus pneumoniae, bacterial chain length and the presence of a capsule are known virulence factors contributing to its ability to cause severe disease.Separation of cultured pneumococci into subpopulations based on morphological type (single cocci,diplococci and chains) will enable more detailed studies of the role they play in virulence. Moreover, wepresent separation of mixed populations of almost genetically identical encapsulated and non-encapsulated pneumococcal strains in our device.
ISSN: 0003-2670
DOI: 10.1016/j.aca.2017.11.050
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Singapore Centre for Environmental Life Sciences Engineering
Rights: © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCELSE Journal Articles

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