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Title: Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity
Authors: Tang, Tommy Hing-Cheung
Alonso, Sylvie
Ng, Lisa Fong-Poh
Thein, Tun-Linn
Pang, Vincent Jun-Xiong
Leo, Yee-Sin
Lye, David Chien-Boon
Yeo, Tsin-Wen
Keywords: Serum hyaluronic acid (HA)
Plasma Leakage
Issue Date: 2017
Source: Tang, T. H. -C., Alonso, S., Ng, L. F. -P., Thein, T. -L., Pang, V. J. -X., Leo, Y. -S., et al. (2017). Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity. Scientific Reports, 7, 46191-.
Series/Report no.: Scientific Reports
Abstract: Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence.
ISSN: 2045-2322
DOI: 10.1038/srep46191
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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