Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMansoor, Hassanen
dc.contributor.authorOng, Hon Shingen
dc.contributor.authorRiau, Andri K.en
dc.contributor.authorStanzel, Tisha P.en
dc.contributor.authorMehta, Jodhbir Singhen
dc.contributor.authorYam, Gary Hin-Faien
dc.identifier.citationMansoor, H., Ong, H. S., Riau, A. K., Stanzel, T. P., Mehta, J. S., & Yam, G. H.-F. (2019). Current Trends and Future Perspective of Mesenchymal Stem Cells and Exosomes in Corneal Diseases. International Journal of Molecular Sciences, 20(12), 2853-. doi:10.3390/ijms20122853en
dc.description.abstractThe corneal functions (transparency, refractivity and mechanical strength) deteriorate in many corneal diseases but can be restored after corneal transplantation (penetrating and lamellar keratoplasties). However, the global shortage of transplantable donor corneas remains significant and patients are subject to life-long risk of immune response and graft rejection. Various studies have shown the differentiation of multipotent mesenchymal stem cells (MSCs) into various corneal cell types. With the unique properties of immunomodulation, anti-angiogenesis and anti-inflammation, they offer the advantages in corneal reconstruction. These effects are widely mediated by MSC differentiation and paracrine signaling via exosomes. Besides the cell-free nature of exosomes in circumventing the problems of cell-fate control and tumorigenesis, the vesicle content can be genetically modified for optimal therapeutic affinity. The pharmacology and toxicology, xeno-free processing with sustained delivery, scale-up production in compliant to Good Manufacturing Practice regulations, and cost-effectiveness are the current foci of research. Routes of administration via injection, topical and/or engineered bioscaffolds are also explored for its applicability in treating corneal diseases.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.format.extent28 p.en
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen
dc.rights© 2019 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.subjectMesenchymal Stem Cellsen
dc.titleCurrent trends and future perspective of mesenchymal stem cells and exosomes in corneal diseasesen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.description.versionPublished versionen
item.fulltextWith Fulltext-
Appears in Collections:MSE Journal Articles
Files in This Item:
File Description SizeFormat 
Current Trends and Future Perspective of.pdf2 MBAdobe PDFThumbnail

Citations 5

Updated on Jul 12, 2024

Web of ScienceTM
Citations 10

Updated on Oct 26, 2023

Page view(s)

Updated on Jul 12, 2024

Download(s) 50

Updated on Jul 12, 2024

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.