Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83296
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dc.contributor.authorCui, Dongen
dc.contributor.authorHuang, Jiaguoen
dc.contributor.authorZhen, Xuen
dc.contributor.authorLi, Jingchaoen
dc.contributor.authorJiang, Yuyanen
dc.contributor.authorPu, Kanyien
dc.date.accessioned2019-10-08T06:14:24Zen
dc.date.accessioned2019-12-06T15:19:28Z-
dc.date.available2019-10-08T06:14:24Zen
dc.date.available2019-12-06T15:19:28Z-
dc.date.copyright2019en
dc.date.issued2019en
dc.identifier.citationCui, D., Huang, J., Zhen, X., Li, J., Jiang, Y., & Pu, K. (2019). A semiconducting polymer nano‐prodrug for hypoxia‐activated photodynamic cancer therapy. Angewandte Chemie, 131(18), 5981-5985. doi:10.1002/ange.201814730en
dc.identifier.issn1433-7851en
dc.identifier.urihttps://hdl.handle.net/10356/83296-
dc.description.abstractPhotodynamic therapy (PDT) holds great promise for cancer therapy; however, its efficacy is often compromised by tumor hypoxia. Herein, we report the synthesis of a semiconducting polymer nanoprodrug (SPNpd) that not only efficiently generates singlet oxygen (1O2) under NIR photoirradiation but also specifically activates its chemotherapeutic action in hypoxic tumor microenvironment. SPNpd is selfassembled from a amphiphilic polymer brush, which comprises a light-responsive photodynamic backbone grafted with poly(ethylene glycol) and conjugated with a chemodrug through hypoxia-cleavable linkers. The well-defined and compact nanostructure of SPNpd (30 nm) enables accumulation in the tumor of living mice. Owing to these features, SPNpd exerts synergistic photodynamic and chemo-therapy, and effectively inhibits tumor growth in a xenograft tumor mouse model. This study represents the first hypoxia-activatable phototherapeutic polymeric prodrug system with a high potential for cancer therapy.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent5 p.en
dc.language.isoenen
dc.relation.ispartofseriesAngewandte Chemie International Editionen
dc.rightsThis is the peer reviewed version of the following article: Cui, D., Huang, J., Zhen, X., Li, J., Jiang, Y., & Pu, K. (2019). A semiconducting polymer nano‐prodrug for hypoxia‐activated photodynamic cancer therapy. Angewandte Chemie, 131(18), 5981-5985, which has been published in final form at https://doi.org/10.1002/ange.201814730. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectPhotodynamic Therapyen
dc.subjectCancer Therapyen
dc.subjectEngineering::Chemical engineeringen
dc.titleA semiconducting polymer nano-prodrug for hypoxia-activated synergetic photodynamic cancer therapyen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.identifier.doi10.1002/ange.201814730en
dc.description.versionAccepted versionen
dc.identifier.rims214922en
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Appears in Collections:SCBE Journal Articles
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