Please use this identifier to cite or link to this item:
Title: Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies
Authors: Palermo, Giulia
Magistrato, Alessandra
Riedel, Tina
Erlach, Thibaud von
Davey, Curt Alexander
Dyson, Paul J.
Rothlisberger, Ursula
Keywords: drug design
metal complexes
Issue Date: 2016
Source: Palermo, G., Magistrato, A., Riedel, T., Erlach, T., Davey, C. A., Dyson, P. J., et al. (2016). Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies. ChemMedChem, 11(12), 1199-1210.
Series/Report no.: ChemMedChem
Abstract: Many transition metal complexes have unique physicochemical properties that can be efficiently exploited in medicinal chemistry for cancer treatment. Traditionally, double-stranded DNA has been assumed to be the main binding target; however, recent studies have shown that nucleosomal DNA as well as proteins can act as dominant molecular binding partners. This has raised new questions about the molecular determinants that govern DNA versus protein binding selectivity, and has offered new ways to rationalize their biological activity and possible side effects. To address these questions, molecular simulations at an atomistic level of detail have been used to complement, support, and rationalize experimental data. Herein we review some relevant studies—focused on platinum and ruthenium compounds—to illustrate the power of state-of-the-art molecular simulation techniques and to demonstrate how the interplay between molecular simulations and experiments can make important contributions to elucidating the target preferences of some promising transition metal anticancer agents. This contribution aims at providing relevant information that may help in the rational design of novel drug-discovery strategies.
ISSN: 1860-7179
DOI: 10.1002/cmdc.201500478
Schools: School of Biological Sciences 
Rights: © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

Citations 5

Updated on Jun 14, 2024

Web of ScienceTM
Citations 5

Updated on Oct 25, 2023

Page view(s)

Updated on Jun 21, 2024

Download(s) 10

Updated on Jun 21, 2024

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.