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Title: Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014–2015
Authors: Hurt, Aeron C.
Besselaar, Terry G.
Tilmanis, Danielle
Wang, Dayan
Zhang, Wenqing
Meijer, Adam
Daniels, Rod S.
Ermetal, Burcu
Fry, Alicia
Gubareva, Larisa
Huang, Weijuan
Lackenby, Angie
Lee, Raphael T.C.
Lo, Janice
Maurer-Stroh, Sebastian
Nguyen, Ha T.
Pereyaslov, Dmitriy
Rebelo-de-Andrade, Helena
Siqueira, Marilda M.
Takashita, Emi
Tashiro, Masato
Keywords: Influenza virus
Antiviral resistance
Issue Date: 2016
Source: Hurt, A. C., Besselaar, T. G., Daniels, R. S., Ermetal, B., Fry, A., Gubareva, L., et al. (2016). Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014–2015. Antiviral Research, 132, 178-185.
Series/Report no.: Antiviral Research
Abstract: The World Health Organization (WHO) Collaborating Centres for Reference and Research on Influenza (WHO CCs) tested 13,312 viruses collected by WHO recognized National Influenza Centres between May 2014 and May 2015 to determine 50% inhibitory concentration (IC50) data for neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, peramivir and laninamivir. Ninety-four per cent of the viruses tested by the WHO CCs were from three WHO regions: Western Pacific, the Americas and Europe. Approximately 0.5% (n = 68) of viruses showed either highly reduced inhibition (HRI) or reduced inhibition (RI) (n = 56) against at least one of the four NAIs. Of the twelve viruses with HRI, six were A(H1N1)pdm09 viruses, three were A(H3N2) viruses and three were B/Yamagata-lineage viruses. The overall frequency of viruses with RI or HRI by the NAIs was lower than that observed in 2013–14 (1.9%), but similar to the 2012–13 period (0.6%). Based on the current analysis, the NAIs remain an appropriate choice for the treatment and prophylaxis of influenza virus infections.
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2016.06.001
Schools: School of Biological Sciences 
Rights: © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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