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Title: Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors
Authors: Tung, Truong Thanh
Jakobsen, Tim Holm
Dao, Trong Tuan
Fuglsang, Anja Thoe
Givskov, Michael
Christensen, Søren Brøgger
Nielsen, John
Keywords: Quorum sensing inhibitors
Fusaric acid
Issue Date: 2016
Source: Tung, T. T., Jakobsen, T. H., Dao, T. T., Fuglsang, A. T., Givskov, M., Christensen, S. B., et al. (2017). Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors. European Journal of Medicinal Chemistry, 126, 1011-1020.
Series/Report no.: European Journal of Medicinal Chemistry
Abstract: Taking advantage of microwave-assisted synthesis, efficient and expedite procedures for preparation of a library of fusaric acid and 39 analogues are reported. The fusaric acid analogues were tested in cell-based screening assays for inhibition of the las and rhl quorum sensing system in Pseudomonas aeruginosa and the lux quorum sensing system in Vibrio fischeri. Eight of the 40 compounds in the library including fusaric acid inhibited lux quorum sensing and one compound inhibited activity of the las quorum sensing system. To our delight, none of the compounds showed growth inhibitory effects in the tested concentration ranges.
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2016.11.044
Organisations: Singapore Centre for Environmental Life Sciences Engineering
Rights: © 2016 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by European Journal of Medicinal Chemistry, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCELSE Journal Articles

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