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Title: Advances in exosome quantification techniques
Authors: Chia, Boon Siew
Low, Yen Peng
Wang, Qing
Li, Pin
Gao, Zhiqiang
Keywords: Exosome
Immunoaffinity capture
Issue Date: 2016
Source: Chia, B. S., Low, Y. P., Wang, Q., Li, P., & Gao, Z. (2017). Advances in exosome quantification techniques. TrAC Trends in Analytical Chemistry, 86, 93-106.
Series/Report no.: TrAC Trends in Analytical Chemistry
Abstract: Accumulated evidence has indicated that exosomes play a vital role in many biological processes such as intercellular communication, antigen presentation, and waste management. Since the fingerprints of exosomes resemble their parental cells, they are widely recognized as next generation biomarkers for disease diagnosis, prognosis, and therapy. Being endogenous in nature, exosomes also present themselves as an exquisite vehicle for the delivery of therapeutic cargoes because of their immunological inertness and exceptional ability to elicit potent cellular responses. Therefore, the quantification of exosomes is crucial in facilitating exosome research and applications. In this article, we summarize the progress in exosome quantification techniques with representative examples to illustrate their working principles with some discussion on challenges and prospects. We hope that this article will offer an overview of exosome quantification techniques and open up new avenues towards the development innovative concepts and instruments for exosome research and applications.
ISSN: 0165-9936
DOI: 10.1016/j.trac.2016.10.012
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2016 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by TrAC Trends in Analytical Chemistry, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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