Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83498
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dc.contributor.authorKonstantopoulos, Arisen
dc.contributor.authorLiu, Yu-Chien
dc.contributor.authorTeo, Ericia Pei Wenen
dc.contributor.authorLwin, Nyein Chanen
dc.contributor.authorYam, Gary Hin Faien
dc.contributor.authorMehta, Jodhbir Singhen
dc.contributor.editorLai, Jui-Yangen
dc.date.accessioned2017-06-08T08:37:27Zen
dc.date.accessioned2019-12-06T15:24:19Z-
dc.date.available2017-06-08T08:37:27Zen
dc.date.available2019-12-06T15:24:19Z-
dc.date.issued2017en
dc.identifier.citationKonstantopoulos, A., Liu, Y.-C., Teo, E. P. W., Lwin, N. C., Yam, G. H. F., & Mehta, J. S. (2017). Early wound healing and refractive response of different pocket configurations following presbyopic inlay implantation. PLOS ONE, 12(2), e0172014-.en
dc.identifier.issn1932-6203en
dc.identifier.urihttps://hdl.handle.net/10356/83498-
dc.description.abstractBackground: Presbyopic inlays have mostly been implanted under a corneal flap. Implantation in a pocket has advantages including less postoperative dry eye and neurotrophic effect, and better biomechanical corneal stability. This study investigated the effect of different pocket and flocket dimensions on corneal stability and refractive power after Raindrop™ implantation, and the associated wound healing response. Methodology: Ten New Zealand White rabbits had bilateral pocket Raindrop™ implantation. Eyes were allocated to 4 groups: pockets with 4mm, 6mm, and 8mm diameters, and 8mm flocket. They were examined pre-operatively, at day 1, weeks 1, 2, 3 and 4 post-surgery with anterior segment optical coherence tomography, corneal topography and in-vivo confocal microscopy. After euthanasia (week 4), CD11b, heat shock protein (HSP) 47 and fibronectin corneal immunohistochemistry was performed. Results: Corneal thickness (mean±SD) increased from 360.0±16.2μm pre-operatively to 383.9±32.5, 409.4±79.3, 393.6±35.2, 396.4±50.7 and 405±20.3μm on day 1, weeks 1,2,3 and 4 respectively (p<0.008, all time-points). Corneal refractive power increased by 11.1±5.5, 7.5±2.5, 7.5±3.1, 7.0±3.6 and 6.3±2.9D (p<0.001). Corneal astigmatism increased from 1.1±0.3D to 2.3±1.6, 1.7±0.7, 1.8±1.0, 1.6±0.9 and 1.6±0.9D respectively (p = 0.033). CT, refractive power change and astigmatism were not different between groups. The 8mm pocket and 8mm flocket groups had the least stromal keratocyte reflectivity. CD11b, fibronectin or HSP47 weren’t detected. Conclusions: Anatomical and refractive stability was achieved by 1 week; the outcomes were not affected by pocket or flocket configuration. No scarring or inflammation was identified. The 8mm pocket and flocket showed the least keratocyte activation, suggesting they might be the preferred configuration.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.format.extent15 p.en
dc.language.isoenen
dc.relation.ispartofseriesPLOS ONEen
dc.rights© 2017 Konstantopoulos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectCorneaen
dc.subjectRabbitsen
dc.titleEarly wound healing and refractive response of different pocket configurations following presbyopic inlay implantationen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.identifier.doi10.1371/journal.pone.0172014en
dc.description.versionPublished versionen
item.grantfulltextopen-
item.fulltextWith Fulltext-
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