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Title: A targeted illumination optical fiber probe for high resolution fluorescence imaging and optical switching
Authors: Shinde, Anant
Perinchery, Sandeep Menon
Murukeshan, Vadakke Matham
Keywords: Biophotonics
Issue Date: 2017
Source: Shinde, A., Perinchery, S. M., & Murukeshan, V. M. (2017). A targeted illumination optical fiber probe for high resolution fluorescence imaging and optical switching. Scientific Reports, 7, 45654-.
Series/Report no.: Scientific Reports
Abstract: An optical imaging probe with targeted multispectral and spatiotemporal illumination features has applications in many diagnostic biomedical studies. However, these systems are mostly adapted in conventional microscopes, limiting their use for in vitro applications. We present a variable resolution imaging probe using a digital micromirror device (DMD) with an achievable maximum lateral resolution of 2.7 μm and an axial resolution of 5.5 μm, along with precise shape selective targeted illumination ability. We have demonstrated switching of different wavelengths to image multiple regions in the field of view. Moreover, the targeted illumination feature allows enhanced image contrast by time averaged imaging of selected regions with different optical exposure. The region specific multidirectional scanning feature of this probe has facilitated high speed targeted confocal imaging.
ISSN: 2045-2322
DOI: 10.1038/srep45654
Schools: School of Mechanical and Aerospace Engineering 
Rights: © 2017 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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