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Title: Vaccination with sporozoites : models and correlates of protection
Authors: Goh, Yun Shan
McGuire, Daniel
Rénia, Laurent
Keywords: Malaria
Science::Biological sciences
Plasmodium Falciparum
Issue Date: 2019
Source: Goh, Y. S., McGuire, D., & Rénia, L. (2019). Vaccination With Sporozoites: Models and Correlates of Protection. Frontiers in Immunology, 10, 1227-. doi:10.3389/fimmu.2019.01227
Series/Report no.: Frontiers in Immunology
Abstract: Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, vaccines are critical to reduce mortality and morbidity. Hence, there are numerous studies investigating various malaria vaccine candidates. Most of the malaria vaccine candidates are subunit vaccines. However, they have shown limited efficacy in Phase II and III studies. To date, only whole parasite formulations have been shown to induce sterile immunity in human. In this article, we review and discuss the recent developments in vaccination with sporozoites and the mechanisms of protection involved.
DOI: 10.3389/fimmu.2019.01227
Schools: School of Biological Sciences 
Rights: © 2019 Goh, McGuire and Rénia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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