Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83533
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dc.contributor.authorGoh, Yun Shanen
dc.contributor.authorMcGuire, Danielen
dc.contributor.authorRénia, Laurenten
dc.date.accessioned2019-08-23T02:58:42Zen
dc.date.accessioned2019-12-06T15:25:01Z-
dc.date.available2019-08-23T02:58:42Zen
dc.date.available2019-12-06T15:25:01Z-
dc.date.issued2019en
dc.identifier.citationGoh, Y. S., McGuire, D., & Rénia, L. (2019). Vaccination With Sporozoites: Models and Correlates of Protection. Frontiers in Immunology, 10, 1227-. doi:10.3389/fimmu.2019.01227en
dc.identifier.urihttps://hdl.handle.net/10356/83533-
dc.description.abstractDespite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, vaccines are critical to reduce mortality and morbidity. Hence, there are numerous studies investigating various malaria vaccine candidates. Most of the malaria vaccine candidates are subunit vaccines. However, they have shown limited efficacy in Phase II and III studies. To date, only whole parasite formulations have been shown to induce sterile immunity in human. In this article, we review and discuss the recent developments in vaccination with sporozoites and the mechanisms of protection involved.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.format.extent18 p.en
dc.language.isoenen
dc.relation.ispartofseriesFrontiers in Immunologyen
dc.rights© 2019 Goh, McGuire and Rénia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectMalariaen
dc.subjectScience::Biological sciencesen
dc.subjectPlasmodium Falciparumen
dc.titleVaccination with sporozoites : models and correlates of protectionen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.3389/fimmu.2019.01227en
dc.description.versionPublished versionen
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