Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83567
Title: Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
Authors: Park, Jung Eun
Sun, Yang
Lim, Sai Kiang
Tam, James P.
Dekker, Matthijs
Chen, Hong
Sze, Siu Kwan
Keywords: Cancer epigenetics
Cancer prevention
Issue Date: 2017
Source: Park, J. E., Sun, Y., Lim, S. K., Tam, J. P., Dekker, M., Chen, H., et al. (2017). Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers. Scientific Reports, 7, 40569-.
Series/Report no.: Scientific Reports
Abstract: Dietary intake of bioactive phytochemicals including the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC) can reduce risk of human cancers, but possible epigenetic mechanisms of these effects are yet unknown. We therefore sought to identify the molecular basis of PEITC-mediated epigenetic tumor restriction. Colon cancer cells treated with low-dose PEITC for >1 month exhibited stable alterations in expression profile of epigenetic writers/erasers and chromatin-binding of histone deacetylases (HDACs) and Polycomb-group (PcG) proteins. Sustained PEITC exposure not only blocked HDAC binding to euchromatin but was also associated with hypomethylation of PcG target genes that are typically hypermethylated in cancer. Furthermore, PEITC treatment induced expression of pro-apoptotic genes in tumor cells, which was partially reversed by overexpression of PcG member BMI-1, suggesting opposing roles for PEITC and PcG proteins in control of tumor progression. These data demonstrate that PEITC regulates chromatin binding of key epigenetic writers/erasers and PcG complexes to restrict tumor development.
URI: https://hdl.handle.net/10356/83567
http://hdl.handle.net/10220/42652
ISSN: 2045-2322
DOI: 10.1038/srep40569
Rights: © 2017 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.