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dc.contributor.authorPark, Jung Eunen
dc.contributor.authorSun, Yangen
dc.contributor.authorLim, Sai Kiangen
dc.contributor.authorTam, James P.en
dc.contributor.authorDekker, Matthijsen
dc.contributor.authorChen, Hongen
dc.contributor.authorSze, Siu Kwanen
dc.identifier.citationPark, J. E., Sun, Y., Lim, S. K., Tam, J. P., Dekker, M., Chen, H., et al. (2017). Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers. Scientific Reports, 7, 40569-.en
dc.description.abstractDietary intake of bioactive phytochemicals including the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC) can reduce risk of human cancers, but possible epigenetic mechanisms of these effects are yet unknown. We therefore sought to identify the molecular basis of PEITC-mediated epigenetic tumor restriction. Colon cancer cells treated with low-dose PEITC for >1 month exhibited stable alterations in expression profile of epigenetic writers/erasers and chromatin-binding of histone deacetylases (HDACs) and Polycomb-group (PcG) proteins. Sustained PEITC exposure not only blocked HDAC binding to euchromatin but was also associated with hypomethylation of PcG target genes that are typically hypermethylated in cancer. Furthermore, PEITC treatment induced expression of pro-apoptotic genes in tumor cells, which was partially reversed by overexpression of PcG member BMI-1, suggesting opposing roles for PEITC and PcG proteins in control of tumor progression. These data demonstrate that PEITC regulates chromatin binding of key epigenetic writers/erasers and PcG complexes to restrict tumor development.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent13 p.en
dc.relation.ispartofseriesScientific Reportsen
dc.rights© 2017 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
dc.subjectCancer epigeneticsen
dc.subjectCancer preventionen
dc.titleDietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasersen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.versionPublished versionen
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