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Title: Selective and Catalyst-free Oxidation of D-Glucose to D-Glucuronic acid induced by High-Frequency Ultrasound
Authors: Amaniampong, Prince N.
Karam, Ayman
Trinh, Quang Thang
Xu, Kai
Hirao, Hajime
Jérôme, François
Chatel, Gregory
Keywords: Chemical engineering
Green chemistry
Issue Date: 2017
Source: Amaniampong, P. N., Karam, A., Trinh, Q. T., Xu, K., Hirao, H., Jérôme, F., et al. (2017). Selective and Catalyst-free Oxidation of D-Glucose to D-Glucuronic acid induced by High-Frequency Ultrasound. Scientific Reports, 7, 40650-.
Series/Report no.: Scientific Reports
Abstract: This systematic experimental investigation reveals that high-frequency ultrasound irradiation (550 kHz) induced oxidation of D-glucose to glucuronic acid in excellent yield without assistance of any (bio)catalyst. Oxidation is induced thanks to the in situ production of radical species in water. Experiments show that the dissolved gases play an important role in governing the nature of generated radical species and thus the selectivity for glucuronic acid. Importantly, this process yields glucuronic acid instead of glucuronate salt typically obtained via conventional (bio)catalyst routes, which is of huge interest in respect of downstream processing. Investigations using disaccharides revealed that radicals generated by high frequency ultrasound were also capable of promoting tandem hydrolysis/oxidation reactions.
ISSN: 2045-2322
DOI: 10.1038/srep40650
Schools: School of Physical and Mathematical Sciences 
Rights: © 2017 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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