Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTan, Nguan Soonen
dc.contributor.authorVázquez-Carrera, Manuelen
dc.contributor.authorMontagner, Alexandraen
dc.contributor.authorSng, Ming Keaten
dc.contributor.authorGuillou, Hervéen
dc.contributor.authorWahli, Walteren
dc.identifier.citationTan, N. S., Vázquez-Carrera, M., Montagner, A., Sng, M. K., Guillou, H., & Wahli, W. (2016). Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ. Progress in Lipid Research, 64, 98-122.en
dc.description.abstractPeroxisome proliferator-activated receptors (PPARs) are a class of transcription factors that belong to the nuclear hormone receptor superfamily, and their activities are dependent on their respective ligands. Since the discovery of PPARα (NR1C1) as a receptor that mediates peroxisome proliferation in rodent hepatocytes in 1990 [1], two other isotypes, PPARβ/δ (NR1C2) and PPARγ (NR1C3), were subsequently identified and characterized [2,3]. Members of the PPAR family have been extensively linked to numerous systemic and cellular activities that range far beyond simply mediating peroxisome proliferation in rodents [4]. Dependent on isotype-specific or shared tissue expression, all three PPARs regulate different or, in some cases, overlapping functions [5]. PPARα and PPARγ have established roles in fatty acid (FA) catabolism and in adipocyte differentiation and lipid storage, respectively, and both are pharmacological targets of FDA-approved drugs for the treatment of numerous metabolic diseases [6,7]. In contrast, no PPARβ/δ ligands are currently used in the treatment of any disease, although small studies on human subjects have used PPARβ/δ ligands to treat metabolic syndrome [8,9]. PPARβ/δ is expressed in numerous tissues [10,11], and many important functions have been attributed to PPARβ/δ in skeletal muscle, adipose tissue, the cardiovascular system, uterine implantation, the gut, the brain, and skin [12]. These factors make PPARβ/δ a very attractive and challenging target, as it is involved in numerous key functions, such as energy metabolism, cellular differentiation and proliferation, tissue repair, and cancer progression.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.description.sponsorshipMOH (Min. of Health, S’pore)en
dc.format.extent121 p.en
dc.relation.ispartofseriesProgress in Lipid Researchen
dc.rights© 2016 Elsevier Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Progress in Lipid Research, Elsevier Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].en
dc.subjectPeroxisome Proliferator-Activated Receptorsen
dc.titleTranscriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.description.versionAccepted versionen
item.fulltextWith Fulltext-
Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles

Citations 10

Updated on Mar 18, 2023

Web of ScienceTM
Citations 5

Updated on Mar 17, 2023

Page view(s) 20

Updated on Mar 24, 2023

Download(s) 20

Updated on Mar 24, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.