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Title: Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ
Authors: Tan, Nguan Soon
Vázquez-Carrera, Manuel
Montagner, Alexandra
Sng, Ming Keat
Guillou, Hervé
Wahli, Walter
Keywords: Peroxisome Proliferator-Activated Receptors
Issue Date: 2016
Source: Tan, N. S., Vázquez-Carrera, M., Montagner, A., Sng, M. K., Guillou, H., & Wahli, W. (2016). Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ. Progress in Lipid Research, 64, 98-122.
Series/Report no.: Progress in Lipid Research
Abstract: Peroxisome proliferator-activated receptors (PPARs) are a class of transcription factors that belong to the nuclear hormone receptor superfamily, and their activities are dependent on their respective ligands. Since the discovery of PPARα (NR1C1) as a receptor that mediates peroxisome proliferation in rodent hepatocytes in 1990 [1], two other isotypes, PPARβ/δ (NR1C2) and PPARγ (NR1C3), were subsequently identified and characterized [2,3]. Members of the PPAR family have been extensively linked to numerous systemic and cellular activities that range far beyond simply mediating peroxisome proliferation in rodents [4]. Dependent on isotype-specific or shared tissue expression, all three PPARs regulate different or, in some cases, overlapping functions [5]. PPARα and PPARγ have established roles in fatty acid (FA) catabolism and in adipocyte differentiation and lipid storage, respectively, and both are pharmacological targets of FDA-approved drugs for the treatment of numerous metabolic diseases [6,7]. In contrast, no PPARβ/δ ligands are currently used in the treatment of any disease, although small studies on human subjects have used PPARβ/δ ligands to treat metabolic syndrome [8,9]. PPARβ/δ is expressed in numerous tissues [10,11], and many important functions have been attributed to PPARβ/δ in skeletal muscle, adipose tissue, the cardiovascular system, uterine implantation, the gut, the brain, and skin [12]. These factors make PPARβ/δ a very attractive and challenging target, as it is involved in numerous key functions, such as energy metabolism, cellular differentiation and proliferation, tissue repair, and cancer progression.
ISSN: 0163-7827
DOI: 10.1016/j.plipres.2016.09.001
Rights: © 2016 Elsevier Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Progress in Lipid Research, Elsevier Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
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