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Title: Global transcriptomic responses of Escherichia coli K-12 to volatile organic compounds
Authors: Yung, Pui Yi
Grasso, Letizia Lo
Mohidin, Abeed Fatima
Acerbi, Enzo
Hinks, Jamie
Seviour, Thomas
Marsili, Enrico
Lauro, Federico M.
Keywords: DRNTU::Engineering::Environmental engineering
Volatile Organic Compounds
Escherichia Coli K12
Issue Date: 2016
Source: Yung, P. Y., Grasso, L. L., Mohidin, A. F., Acerbi, E., Hinks, J., Seviour, T., . . . Lauro, F. M. (2016). Global transcriptomic responses of Escherichia coli K-12 to volatile organic compounds. Scientific Reports, 6,19899-. doi:10.1038/srep19899
Series/Report no.: Scientific Reports
Abstract: Volatile organic compounds (VOCs) are commonly used as solvents in various industrial settings. Many of them present a challenge to receiving environments, due to their toxicity and low bioavailability for degradation. Microorganisms are capable of sensing and responding to their surroundings and this makes them ideal detectors for toxic compounds. This study investigates the global transcriptomic responses of Escherichia coli K-12 to selected VOCs at sub-toxic levels. Cells grown in the presence of VOCs were harvested during exponential growth, followed by whole transcriptome shotgun sequencing (RNAseq). The analysis of the data revealed both shared and unique genetic responses compared to cells without exposure to VOCs.
DOI: 10.1038/srep19899
Schools: School of Chemical and Biomedical Engineering 
Asian School of the Environment 
Organisations: Singapore Centre for Environmental Life Sciences Engineering
Rights: © 2016 The Authors (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:ASE Journal Articles
SCBE Journal Articles
SCELSE Journal Articles

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