Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83599
Title: Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease
Authors: Bose, Tanima
Lee, Ryan
Hou, Aihua
Tong, Louis
Chandy, Kanianthara George
Keywords: Immunology
Drug discovery
Issue Date: 2017
Source: Bose, T., Lee, R., Hou, A., Tong, L., & Chandy, K. G. (2017). Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease. Scientific Reports, 7, 45312-.
Series/Report no.: Scientific Reports
Abstract: Non-recirculating resident memory (TRM) and recirculating T cells mount vigorous immune responses to both self and foreign antigens in barrier tissues like the skin, lung and gastrointestinal tract. Using impression cytology followed by flow cytometry we identified two TRM subsets and four recirculating T-subsets in the healthy human ocular surface. In dry eye disease, principal component analysis (PCA) revealed two clusters of patients with distinct T-cell signatures. Increased conjunctival central memory and naïve T cells characterized Cluster-1 patients, and increased CD8+ TRMs and CD4+ recirculating memory T cells characterized Cluster-2 patients. Interestingly these T-cell signatures are associated with different clinical features: the first signature correlated with increased ocular redness, and the second with reduced tear break up times. These findings open the door to immune-based characterization of dry eye disease and T-subset specific immunotherapies to suppress T-subsets involved in disease. They may also help with patient stratification during clinical trials of immunomodulators.
URI: https://hdl.handle.net/10356/83599
http://hdl.handle.net/10220/42680
ISSN: 2045-2322
DOI: 10.1038/srep45312
Rights: © 2017 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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